Effect of Septilin--a herbal preparation on pharmacokinetics of carbamazepine in rabbits.
نویسندگان
چکیده
The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-administration of Septilin. We conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.
منابع مشابه
[Indian Journal of Physiology and Pharmacology (1998): (42), 4, 527]
The study was carried out in rabbits, to see the effect of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1⁄2a. t 1/2e. AUCo-α of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine also reduced significantly in comparison to those of control rabbits after 7 days coadministration of ...
متن کاملAnti-inflammatory and analgesic effect of herbal preparation: septilin.
Septilin a proprietary herbal preparation has been reported to have wound healing and immunomodulatory properties. The present study was, therefore, designed to ascertain the anti-inflammatory and analgesic properties of septilin in rats and mice by oral route. Anti-inflammatory activity was assessed by using acute (carrageenan-induced paw oedema), sub-acute (cotton pellet granuloma) and chroni...
متن کاملEffect of herbal preparation on immune response of immunosuppressed mice.
The present study was undertaken to study the effect of a herbal formulation (Septilin) as immunomodulator, on immune response in mice. The study of this formulation in respect to humoral and cell mediated immune response has suggested that, oral administration of Septilin (500 mg/kg) alone or in combination with an immuno-suppressive drug (prednisolone 4 mg/kg), enhances both primary and secon...
متن کاملEffect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits.
The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentr...
متن کاملSeptilin in Infective Dermatoses
INTRODUCTION Septilin is an Ayurvedic preparation which contains antibacterial and anti-inflammatory principles. Septilin has been reported to stimulate phagocytosis. Cahu and Hirsh (1960) demonstrated the presence of an antibacterial protein (phagocytin) in the cytoplasmic granules of polymorphs. This protein of polymorphs has an antibacterial effect on both gram-positive and gram-negative org...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 42 4 شماره
صفحات -
تاریخ انتشار 1998